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Journal of Diabetes Research
Volume 2016, Article ID 8163474, 9 pages
http://dx.doi.org/10.1155/2016/8163474
Research Article

Insulin Resistance and Obesity Affect Lipid Profile in the Salivary Glands

1County Veterinary Inspection, 26B Zwycięstwa Street, 15-959 Białystok, Poland
2Department of Conservative Dentistry, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland
3Department of Physiology, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland
4Institute of Health Care Higher Vocational School, 10 Noniewicza Street, 16-400 Suwałki, Poland
5Students’ Scientific Group “Stomatological Biochemistry”, Department of Conservative Dentistry, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland
6Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 2C Mickiewicza Street, 15-222 Białystok, Poland
7Department of Public Health, Medical University of Bialystok, 1 Kilińskiego Street, 15-222 Białystok, Poland

Received 22 December 2015; Revised 28 March 2016; Accepted 11 April 2016

Academic Editor: Jose López-López

Copyright © 2016 Jan Matczuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In today’s world wrong nutritional habits together with a low level of physical activity have given rise to the development of obesity and its comorbidity, insulin resistance. More specifically, many researches indicate that lipids are vitally involved in the onset of a peripheral tissue (e.g., skeletal muscle, heart, and liver) insulin resistance. Moreover, it seems that diabetes can also induce changes in respect of lipid composition of both the salivary glands and saliva. However, judging by the number of research articles, the salivary glands lipid profile still has not been sufficiently explored. In the current study we aim to assess the changes in the main lipid fractions, namely, triacylglycerols, phospholipids, free fatty acids, and diacylglycerols, in the parotid and the submandibular salivary glands of rats exposed to a 5-week high fat diet regimen. We observed that the high caloric fat diet caused a significant change in the salivary glands lipid composition, especially with respect to PH and TG, but not DAG or FFAs, classes. The observed reduction in PH concentration is an interesting phenomenon frequently signifying the atrophy and malfunctions in the saliva secreting organs. On the other hand, the increased accumulation of TG in the glands may be an important clinical manifestation of metabolic syndrome and type 2 diabetes mellitus.