Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

Figure 5

Effects of RO4987655 on pERK1/2 in (a) liver, (b) soleus muscle, and (c) epididymal adipose tissue from db/db mice. RO4987655 was administered as a dietary admixture at the indicated dosages (mg in 1 kg CE-2; numbers on the -axis) for 17 days. Representative blots from each type of tissue are shown at the top of the figures. Data are expressed as mean ± SEM, . < 0.05, < 0.01, and < 0.001 versus control group (0 mg in 1 kg CE-2) by parametric Dunnett’s multiple comparison test.

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