Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

Figure 6

Effects of Mek1 (Map2k1) silencing by adenovirus-mediated shRNA expression of Mek1 in db/db mice on (a, b) blood glucose, (c) Mek1 mRNA expression level in the liver, (d) representative blots of MEK1 and MEK2 protein in the liver, and (e, f) MEK1 and MEK2 protein expression level in the liver. Data are expressed as mean ± SEM, . < 0.01 versus scramble by Welch’s test. The lanes were run on the same gel but were noncontiguous. Black bars, vehicle-treated group; white bars, scramble-treated group; hatched bars, Mek1-silenced group.

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