Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance

Table 2

Blood glucose level, glucose infusion rate (GIR), and endogenous glucose production (EGP) of RO4987655-treated db/db mice in the hyperinsulinemic-euglycemic clamp test.

	Control	RO4987655	Pioglitazone
		(8 mg in 1 kg in CE-2)	(200 mg in 1 kg CE-2)
	10	9	10
Blood glucose (mg⋅dL^−1) (4 h fasted)	228.4 ± 34.7	125.4 ± 11.2	142.1 ± 16.0
Blood glucose (mg⋅dL^−1)	103.4 ± 3.3	108.7 ± 1.5	108.1 ± 4.6
GIR (mg⋅kg^−1⋅min^−1)	19.0 ± 1.3	28.2 ± 3.7	35.8 ± 2.0
EGP (mg⋅kg^−1⋅min^−1)	11.9 ± 1.8	6.5 ± 1.9	2.3 ± 2.6
Plasma insulin (ng⋅mL^−1)	40.1 ± 2.6	28.1 ± 4.6	ND

Data are expressed as mean ± SEM.
Mean values of last 60 min on clamp.
, , and versus control by parametric Dunnett’s multiple comparison test.
versus control by parametric Dunnett’s multiple comparison test.
ND, not determined.
and .