Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model

Figure 1

Experimental daily scheme. Blue represents the two insulin administration modes. For the single injection group, 4 UI/200 g of body weight of long-acting insulin was administered each day at 9 am. Analyses were carried out at and  h thereafter. For the continuous insulin administration group (via pumps), a rapid-acting insulin was loaded into the osmotic pump to allow a delivery of 4 UI/200 g of body weight per day. The injection point corresponds to 9 am and analyses were carried out at and  h thereafter.