Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model

Figure 3

Blood glucose levels at  h (a) and  h (b) after insulin injection. At  h, untreated rats (CTL ND and diabetic) had, respectively, normal glycaemia and 6 g/L glucose, the highest value detectable with our material. Pump rats succeeded in achieving normoglycaemia in a few days, whereas the injection group only reached ~4 g/L. Diabetic group is different () from all groups at all times. Injection group is different () from all other groups at all times since day 4 (). Pump group is different () from injection and diabetic group since day 4 (a). On a longer time ( h), CTL ND rats still had a normal blood glucose level, whereas the diabetic and injection groups levelled at 6 g/L. Pump rats still achieved normoglycaemia. Diabetic and injection groups are different () from all groups at all times. pump versus CTL ND at day 7 (b). .

(a)

(b)