Modulation Effect of Peroxisome Proliferator-Activated Receptor Agonists on Lipid Droplet Proteins in Liver

Figure 2

FSP27/CIDEC protein is highly expressed in mouse fatty liver. Immunoblot analyses of FSP27/CIDEC protein abundance in liver lysates (upper panel). Quantification of the protein levels was normalized to β-actin (lower panel). (a) FSP27/CIDEC protein level in liver from C57BL/6 mice fed with a normal chow diet (Chow) or high-fat diet (HF) for 20 weeks or from db/db mice. (b) FSP27/CIDEC protein level in liver from mice fed with HF diet and treated with pioglitazone or fenofibrate. Data are the mean ± SEM (–7). a: versus Chow and b: versus HF; . HF-P: mice fed an HF diet and treated with pioglitazone; HF-F: mice fed an HF diet and treated with fenofibrate.

(a)

(b)