Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Figure 10

Periodic acid-Schiff (PAS) staining of renal glomerular regions from control and diabetic rats at the end of the experiment at week 30. (a) Representative images of PAS-stained kidney specimens from all experimental groups (magnification ×640). Glomerulus from control nondiabetic rat has opened capillary lumens and the fewest amounts of mesangial cells per capillary tuft. Moderate diffuse expansion of mesangium is observed in both diabetic groups. NA-STZ-injected diabetic rat shows markedly more expanded mesangium and endocapillary hypercellularity. (b) Graphic representation of semiquantitative indices of glomerular matrix expansion that, as indicated, are determined from at least 35 glomeruli in each kidney. Means and standard deviations are shown.

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