Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Figure 4

Glucose curves of oral glucose tolerance tests (OGTTs) and area under the curves (AUC) of glucose in the experimental groups. (a) Plasma glucose responses to oral administration of glucose in dose of 3 g/kg during 120 min OGTTs in the control (nondiabetic rats) and groups with diabetes being induced one week earlier (at week 8 of the experiment) by intraperitoneal injections of either a low dose of streptozotocin (LD-STZ) or nicotinamide and streptozotocin (NA-STZ). compared to control nondiabetic group. Nonsignificant difference between NA-STZ and LD-STZ groups is not shown. (b) Total glucose area under the curves (AUC) is presented for comparison between experimental groups. Mean values and standard deviations are shown.

(a)

(b)