Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Table 1

Summary of metabolic parameters and serum levels of urea and creatinine in the control, NA-STZ, and LD-STZ groups measured at 10, 20, and 30 weeks of the experiment. Mean values and standard deviations are shown.   versus NA-STZ: comparison of nicotinamide-streptozotocin-induced diabetic rats and the other two experimental groups at the same point of measurement.   versus LD-STZ: comparison of low-dose-streptozotocin-induced diabetic rats and the other two experimental groups at the same point of measurement. N/A: not assayed.

Experimental groups	Control nondiabetic group			Low-dose streptozotocin-induced diabetic group			Nicotinamide-streptozotocin-induced diabetic group
Parameters; Mean ± standard deviation	Week of the study			Week of the study			Week of the study
	10 weeks	20 weeks	30 weeks	10 weeks	20 weeks	30 weeks	10 weeks	20 weeks	30 weeks
HbA1 c, %	3.6	3.7	4.0	5.45	6.85	6.7	5.39	7.02	6.94
SD	0.29	0.13	0.26	0.61	0.21	0.43	0.34	0.29	0.27
versus  NA-STZ	0.029	0.01	0.016	0.97	0.39	0.46
versus  LD-STZ	0.028	0.029	0.028
Serum insulin level, pmol/L	83.5	96.6	87.8	50.2	54.0	59.6	49.6	51.3	50.9
SD	6.81	9.18	6.24	8.13	10.46	8.93	7.34	8.72	8.85
versus  NA-STZ	0.028	0.009	0.015	0.88	0.76	0.27
versus  LD-STZ	0.03	0.027	0.28
HOMA-IR	1.93	2.23	2.01	2.76	2.78	2.83	3.20	2.87	2.91
SD	0.29	0.14	0.22	0.92	0.93	0.87	0.39	0.22	0.70
versus  NA-STZ	0.028	0.014	0.031	0.31	0.99	0.77
versus  LD-STZ	0.11	0.48	0.06
Total cholesterol, mmol/L	1.55	1.58	1.63	2.83	2.71	2.42	2.89	2.76	2.74
SD	0.35	0.20	0.27	0.35	0.19	0.32	0.25	0.23	0.21
versus  NA-STZ	0.028	0.014	0.002	0.88	0.74	0.11
versus  LD-STZ	0.028	0.031	0.008
Triglycerides, mmol/L	0.57	0.56	0.70	1.13	1.04	0.86	1.05	0.90	0.89
SD	0.08	0.12	0.17	0.49	0.41	0.33	0.18	0.12	0.19
versus  NA-STZ	0.028	0.01	0.029	1.0	0.91	0.98
versus  LD-STZ	0.029	0.057	0.21
Serum urea, mmol/L	N/A	N/A	6.5	N/A	N/A	8.7	N/A	N/A	8.82
SD			0.89			1.18			1.03
versus  NA-STZ			0.06			0.96
versus  LD-STZ			0.012
Serum creatinine, μmol/L	33.5	35.8	41.9	41.3	44.8	61.5	38.3	47.0	69.0
SD	3.42	3.61	4.09	6.24	6.50	11.62	2.99	4.0	4.30
versus  NA-STZ	0.14	0.004	0.002	0.65	0.80	0.31
versus  LD-STZ	0.11	0.038	0.008