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Journal of Diabetes Research
Volume 2016, Article ID 8380279, 7 pages
Research Article

High Serum Adipocyte Fatty Acid Binding Protein Is Associated with Metabolic Syndrome in Patients with Type 2 Diabetes

1Division of Metabolism and Endocrinology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
2School of Medicine, Tzu Chi University, Hualien, Taiwan
3Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
4Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
5Department of Nursing, Tzu Chi University, Hualien, Taiwan

Received 12 September 2016; Revised 31 October 2016; Accepted 9 November 2016

Academic Editor: Osama M. Ahmed

Copyright © 2016 Jer-Chuan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Adipocyte fatty acid binding protein (A-FABP) is a key mediator of obesity-related metabolic syndrome (MetS). The aim of this study was to evaluate the relationship between A-FABP concentration and MetS in type 2 diabetes mellitus (DM) patients. Fasting blood samples were obtained from 165 type 2 DM volunteers. MetS and its components were defined using diagnostic criteria from the International Diabetes Federation. Among 165 DM patients, 113 patients (68.5%) had MetS. Diabetic persons who had MetS had significantly higher A-FABP levels () than those without MetS. Female DM persons had higher A-FABP level than man (). No statistically significant differences in A-FABP levels were found in use of statin, fibrate, or antidiabetic drugs. Multivariate forward stepwise linear regression analysis revealed that body fat mass (), logarithmically transformed creatinine (log-creatinine; ), female DM patients (), and logarithmically transformed high sensitive C-reactive protein (log-hs-CRP; ) were positively correlated, while albumin () and glomerular filtration rate (GFR; ) were negatively correlated with serum A-FABP levels in type 2 DM patients. In this study, higher serum A-FABP level was positively associated with MetS in type 2 DM patients.