PPAR Gamma and Angiogenesis: Endothelial Cells Perspective

Figure 4

Effects of PPARγ activation on angiogenesis. (a) Angiogenic properties of endothelium is decreased upon activation of PPARγ via reduction of migratory properties and inhibited proliferation and by diminished production of angiogenic factors. (b) Stimulation of PPARγ in diabetic endothelial progenitor cells induces angiogenesis. Detailed description of molecular mechanisms responsible for observed effects is in the main text.