Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine

Figure 1

Iron and zinc mediated toxicity in HUVECs (a) and PTECs (b). PTECs were more tolerant to iron toxicity as compared to HUVECs (c). Iron mediated toxicity was not largely influenced by transferrin (TRF) (d). Although PTECs were less susceptible to iron mediated toxicity, toxicity increased upon longer exposure (e). Iron toxicity was associated with an increased number of TUNEL positive cells, which was significantly abrogated by L-carnosine (f).

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