Journal of Diabetes Research / 2016 / Article / Tab 3

Research Article

Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals

Table 3

Genotype distribution across the quarters of global DNA methylation.

CharacteristicGlobal DNA methylation difference-trend HWEβ (95% CI)
Q1Q2Q3Q4

111110112111
Actual% 5mc
 Median0.112.123.947.24
MTHFR rs18011330.6650.2550.697−0.387 (−1.054 to 0.281)
 C/C75 (68.8)78 (71.6)85 (76.6)86 (77.5)
 C/T32 (29.4)27 (24.8)24 (21.6)23 (20.7)
 T/T2 (1.8)4 (3.7)2 (1.8)2 (1.8)
NOS3 rs17999830.1730.2050.5820.943 (0.286 to 1.560)
 G/G82 (76.6)73 (68.9)81 (77.1)65 (62.5)
 G/T23 (21.5)28 (26.4)22 (20.9)36 (34.6)
 T/T2 (1.9)5 (4.7)2 (1.9)3 (2.9)

values from Kruskal-Wallis and chi square tests for the differences across quarters of global DNA methylation.
Beta coefficients and 95% confidence interval from age, gender, and status for hyperglycemia and smoking adjusted linear regressions for the prediction of global DNA methylation by various SNPs assuming a log-additive genetic model.
HWE: Hardy-Weinberg equilibrium.

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