Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals

Table 3

Genotype distribution across the quarters of global DNA methylation.

Characteristic	Global DNA methylation				difference	-trend	HWE	β (95% CI)
	Q1	Q2	Q3	Q4
	111	110	112	111
Actual% 5mc
Median	0.11	2.12	3.94	7.24
MTHFR rs1801133					0.665	0.255	0.697	−0.387 (−1.054 to 0.281)
C/C	75 (68.8)	78 (71.6)	85 (76.6)	86 (77.5)
C/T	32 (29.4)	27 (24.8)	24 (21.6)	23 (20.7)
T/T	2 (1.8)	4 (3.7)	2 (1.8)	2 (1.8)
NOS3 rs1799983					0.173	0.205	0.582	0.943 (0.286 to 1.560)
G/G	82 (76.6)	73 (68.9)	81 (77.1)	65 (62.5)
G/T	23 (21.5)	28 (26.4)	22 (20.9)	36 (34.6)
T/T	2 (1.9)	5 (4.7)	2 (1.9)	3 (2.9)

⁢ values from Kruskal-Wallis and chi square tests for the differences across quarters of global DNA methylation.
Beta coefficients and 95% confidence interval from age, gender, and status for hyperglycemia and smoking adjusted linear regressions for the prediction of global DNA methylation by various SNPs assuming a log-additive genetic model.
HWE: Hardy-Weinberg equilibrium.