Cryoinjury size is increased in the STZ diabetic mouse. TTC stained control (a) and STZ diabetic (b) rat hearts 48 hrs after cryoinjury. TUNEL labeling of sections from control (c) and STZ diabetic (d) rat ventricles 48 hrs after cryoinjury. Epicardial injury area is increased in the STZ diabetic rodent hearts 48 hrs after cryoinjury and this change is rescued by administration of insulin (e, f). There are trends of decreased width of injury border zone (g) and increased TUNEL labeling (h) in the diabetic heart compared to controls. Spaced bars on (a) = 1 mm. Scale Bar (c, d) = 500 μM.