Diabetes Increases Cryoinjury Size with Associated Effects on Cx43 Gap Junction Function and Phosphorylation in the Mouse Heart

Figure 3

Lucifer Yellow dye spread is decreased in insulin-treated hearts. Representative images of Lucifer Yellow dye propagation through the ventricle of control animals and those treated with heptanol and insulin (a). The propagation of Lucifer Yellow is substantially decreased in hearts treated with insulin independent of STZ treatment (b), . Scale bar = 100 μM. Multiple comparisons performed using Kruskal-Wallis test, , applying Dunn’s post hoc testing; CTL versus STZ = ns, CTL versus CTL + insulin, and STZ versus STZ + insulin were significantly different.

(a)

(b)