Diabetes Increases Cryoinjury Size with Associated Effects on Cx43 Gap Junction Function and Phosphorylation in the Mouse Heart

Figure 4

Cx43 phosphorylation at serine 368 is enhanced with insulin administration in the mouse heart. Representative western blot labeling Cx43 phosphorylated at serine 368 (a) and total Cx43 (b) of homogenized ventricles of control mice and those treated with insulin. A significant increase in serine 368/total Cx43 was detected in hearts harvested from insulin-treated animals, (c).

(a)

(b)

(c)