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Journal of Diabetes Research
Volume 2016, Article ID 8797316, 6 pages
http://dx.doi.org/10.1155/2016/8797316
Research Article

Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients

1Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China
2China National Heavy Duty Truck Group Corporation Hospital, Jinan, Shandong 250116, China
3Lukang Hospital of Jining, Jining, Shandong 272141, China
4Department of Endocrinology, Second People’s Hospital of Jining, Jining, Shandong 272049, China
5Shantui Community Health Center, Jining, Shandong 272000, China
6Department of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong 250012, China

Received 13 February 2015; Accepted 26 March 2015

Academic Editor: Francis M. Finucane

Copyright © 2016 Xinguo Hou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate changes in the glycated hemoglobin A1c (A1c) level and those in β cell function and insulin resistance in newly diagnosed and drug naive type 2 diabetes patients and to evaluate the relationship between them. Design and Methods. A total of 818 newly diagnosed diabetic individuals who were ≥40 years of age were recruited. The subjects were grouped by A1c values (<6.5%, 6.5–7%, 7-8%, 8-9%, and ≥9%). The homeostasis model assessment (HOMA) was used to evaluate pancreatic β cell function (HOMA-β) and insulin resistance (HOMA-IR). ANOVA, -tests, and binary logistic regression analysis were used for data analysis. Results. Compared with subjects with A1c values <6.5%, individuals with an A1c of 6.5–7% exhibited an increased HOMA-β index. However, the HOMA-β index was significantly decreased at A1c values ≥7% and further decreased by 9.3% and by 23.7%, respectively, at A1c values of 7-8% and 8-9%. As A1c increased to ≥9%, a 62% reduction in β cell function was observed, independently of age, gender, body mass index (BMI), blood pressure (BP), blood lipids, and hepatic enzyme levels. Meanwhile, insulin resistance was significantly increased with an increase in A1c values. Conclusions. Elevated A1c values (≥7%) were associated with substantial reductions in β cell function.