Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients
Table 3
Logistic regression analysis of the association between different A1c groups and impaired β cell function.
Characteristics
Model 1
Model 2
Model 3
OR (95% CI)
P
OR (95% CI)
P
OR (95% CI)
P
A1c groups
Group 1
1 (reference)
1 (reference)
1 (reference)
Group 2
0.80 (0.45–1.40)
0.427
1.22 (0.65–2.28)
0.536
1.33 (0.70–2.53)
0.377
Group 3
1.47 (0.92–2.37)
0.111
2.47 (1.42–4.27)
0.001
2.79 (1.58–4.94)
<0.001
Group 4
2.45 (1.35–4.48)
0.003
3.69 (1.82–7.48)
<0.001
4.19 (1.99–8.79)
<0.001
Group 5
15.36 (9.05–26.07)
0.014
22.08 (11.86–41.12)
<0.001
28.51 (14.53–55.95)
<0.001
Female
—
0.38 (0.25–0.59)
<0.001
0.39 (0.25–0.61)
<0.001
Age (years)
—
0.99 (0.97–1.01)
0.356
0.99 (0.97–1.02)
0.398
BMI (kg/m2)
—
0.76 (0.70–0.83)
<0.001
0.77 (0.70–0.84)
<0.001
WC (cm)
—
0.99 (0.96–1.02)
0.405
0.99 (0.96–1.02)
0.455
Systolic BP
—
—
0.99 (0.98–1.01)
0.290
Diastolic BP
—
—
1.01 (0.99–1.03)
0.545
Cholesterol
—
—
0.96 (0.77–1.19)
0.699
Triglycerides
—
—
0.86 (0.73–1.02)
0.083
AST
—
—
1.03 (0.99–1.06)
0.155
ALT
—
—
0.98 (0.95–1.01)
0.137
Model 1: unadjusted. Model 2: adjusted for age, gender, BMI, and WC. Model 3: adjusted for age, gender, BMI, WC, Systolic BP, Diastolic BP, Cholesterol, Triglycerides, AST, and ALT.
