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Journal of Diabetes Research
Volume 2016, Article ID 9027484, 8 pages
Research Article

Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer’s Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan

1Department of Endocrinology and Metabolism, Tungs’ Taichung MetroHarbor Hospital, Taichung 435, Taiwan
2Department of Information Management, Hsing Wu University, New Taipei City, Taiwan
3Department of Biomedical Informatics, Asia University, Taichung 413, Taiwan
4Department of Computer Science and Information Engineering, National Central University, Chungli, Taiwan

Received 11 July 2016; Accepted 29 September 2016

Academic Editor: Dilek Yavuz

Copyright © 2016 Cheng-Wei Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Type 2 diabetes mellitus patients are known to have higher risk of developing dementia while aspirin use has been shown to prevent incident dementia. This study was conducted to evaluate the potential benefits of aspirin use on dementia in patients with type 2 diabetes mellitus and identify the appropriate dosage of aspirin that provides the most benefit. Method. A Taiwan nationwide, population-based retrospective 8-year study was employed to analyze the association between the use of aspirin and incidence of dementia including Alzheimer’s disease and non-Alzheimer’s dementia using multivariate Cox-proportional hazards regression model and adjusting for several potential confounders. Results. Regular aspirin use in mean daily dosage of within 40 mg was associated with a decreased risk of developing incident Alzheimer’s dementia in patients with type 2 diabetes mellitus (adjusted HR of 0.51 with 95% CI of 0.27–0.97, value 0.041). Conclusion. A mean daily dosage of aspirin use within 40 mg might decrease the risk of developing Alzheimer’s disease in patients with type 2 diabetes mellitus.