Mean Daily Dosage of Aspirin and the Risk of Incident Alzheimer’s Dementia in Patients with Type 2 Diabetes Mellitus: A Nationwide Retrospective Cohort Study in Taiwan
Table 2
Risk of Alzheimer’s disease, non-Alzheimer dementia, and all-cause dementia among T2DM patients who regularly use aspirin.
Study subjects
All-cause dementia
Aspirin status
Mean daily dose (mg)
Dementia cases/total
Unadjusted HR (95% CI)
p value
Adjusted HR (95% CI)
p value
No aspirin
360/10720
Reference (N/A)
Reference (N/A)
Regular user
117/2876
1.42 (1.15–1.75)
0.001
1.45 (1.15–1.84)
0.002
Cohort 1
<40
11/522
0.55 (0.30–1.00)
0.050
0.48 (0.26–0.89)
0.019
Cohort 2
40–79
39/1003
1.33 (0.95–1.85)
0.096
1.47 (1.03–2.09)
0.033
Cohort 3
≥80
67/1351
2.05 (1.57–2.66)
<0.001
2.35 (1.75–3.15)
<0.001
Study subjects
Alzheimer’s disease
Aspirin status
Mean daily dose (mg)
Dementia cases/total
Unadjusted HR (95% CI)
p value
Adjusted HR (95% CI)
p value
No aspirin
308/10668
Reference (N/A)
Reference (N/A)
Regular user
93/2852
1.33 (1.06–1.68)
0.016
1.37 (1.05–1.78)
0.019
Cohort 1
<40
10/521
0.58 (0.31–1.10)
0.094
0.51 (0.27–0.97)
0.041
Cohort 2
40–79
28/992
1.13 (0.77–1.66)
0.545
1.27 (0.84–1.91)
0.257
Cohort 3
≥80
55/1339
1.99 (1.49–2.66)
<0.001
2.26 (1.64–3.12)
<0.001
Study subjects
Non-Alzheimer dementia
Aspirin status
Mean daily dose (mg)
Dementia cases/total
Unadjusted HR (95% CI)
p value
Adjusted HR (95% CI)
p value
No aspirin
52/10412
Reference (N/A)
Reference (N/A)
Regular user
24/2783
1.94 (1.19–3.16)
0.008
1.91 (1.09–3.36)
0.025
Cohort 1
<40
1/512
0.34 (0.05–2.46)
0.286
0.28 (0.04–2.05)
0.209
Cohort 2
40–79
11/975
2.49 (1.29–4.78)
0.006
2.54 (1.23–5.24)
0.012
Cohort 3
≥80
12/1296
2.42 (1.29–4.57)
0.006
2.95 (1.44–6.05)
0.003
Mean daily dose (mg) = cumulative doses starting from the regular taking drug date to the end of observation date/days between the start regular taking drug date and the end of observation date. Adjust age group, gender, CCI group, stroke types, antidiabetic drugs, statins, and hypertensive drugs. HR: hazard ratio; CI: confidence interval; T2DM: type 2 diabetes mellitus.
