Identification of Candidate Tolerogenic CD8⁺ T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model

Table 1

The amino acid numbers of the primary translation product of each peptide are indicated. Asterisk for indicates amino acid substitution (G>V) at position 9 that was shown to enhance MHC binding stability [22].

Insulin		Insulin
2–10	ALLVHFLPL	6–14	HFLPLLALL
3–11	LLVHFLPLL	22–30	TQAFVKQHL
22–30	TQAFVKQHL	39–47	LYLVCGERV
31–39	CGPHLVEAL	71–79	SPGDLQTLA
70–78	GSPGDLQTL	92–100	QCCTSICSL
95–103	TSICSLYQL
IGRP		IGRP
33–41	GDPRNIFSI	18–26	DYRTYYGFL
207–215	YLKTNVFLF	41–49	IYFPLWFQL
216–225	FALGFYLLL	123–131	WYVMVTAAL
251–259	KWCANPDWI	151–159	SFLWSVFWL
258–265	GLVRNLGVL	206–214	VYLKTNVFL
271–279	FAINSEMFL	255–263	PFAGLVRNL
296–304	CALTSLTTM	392–401	RLLCALTSL
311–319	KIPTHAEPL
ICAp69		ICAp69
62–70	FHSIQRTCL	14–22	RFAQDKSVV
199–207	LAKKNFDKL	78–86	LYQKRICFL
221–229	SRCNLLSHM	111–119	MMQATGKAL
258–266	YQPYEFTTL	189–197	KFRKVQTQV
390–398	AAVFGDDQL	285–293	SWRENREAV
425–433	LLDQNMKDL
GAD65		GAD65
84–92	KGDVNYAFL	178–186	YFNQLSTGL
151–160	DQPQNLEEI	206–214	TYEIAPVFV
243–251	GAISNMYAM	340–348	VYGAFDPLL
389–397	SVTWNPHKM	436–444	SYDTGDKAL
551–559	GDKVNFFRM	546–554	SYQPLGDKV
ZnT8		ZnT8
28–36	QKPVNKDQC	7–15	TYLVNDQAT
76–84	ASAICFIFM	112–120	SFLLSLFSL
77–185	SAICFIFMV	158–166	LYLACERLL
174–182	CAASAICFI	237–245	IYFKPDYKI
186–194	AANIVLTMI	282–290	SYNSVKEII
306–314	SLTVNQVIL	325–333	DSQSVRTGI
DH		DβH
64–72	ELSWNVSYV	233–241	TYWCYITEL
97–105	GEMENADLI	363–371	RYDAGIMEL
411–419	FASQLHTHL	420–428	TGRKVVTVL
548–556	WNSFNRNML	471–479	TYNTENKTL
578–586	PGEWNLQPL	498–506	YYPQTELEL