Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats
Table 1
The effects of central injection of M617 on food intake, body weight, insulin, and plasma free fatty acid levels of rats ().
Food intake (g/d)
Weight (g)
Insulin (mlU/L)
Free fatty acid (mmol/L)
Before
After
Before
After
Before
After
Before
After
NC
14.6 ± 1.0
15.2 ± 1.3
295.6 ± 11.2
302.4 ± 12.9
32.9 ± 4.7
33.1 ± 5.6
0.66 ± 0.6
0.69 ± 0.8
N-M617
14.8 ± 1.4
16.8 ± 1.2
289.9 ± 11.4
316.3 ± 14.1
34.5 ± 6.2
27.8 ± 0.5
0.72 ± 0.7
0.64 ± 0.6
DC
15.7 ± 1.1△
16.6 ± 1.5△
260.1 ± 10.4△△
266.1 ± 11.2△△
37.9 ± 7.7△
40.4 ± 6.8△
1.15 ± 0.9△△
1.24 ± 1.1△△
D-M617
15.9 ± 1.6●
18.1 ± 1.3
255.2 ± 9.8●●
280.3 ± 12.7
39.9 ± 7.9●
35.5 ± 6.6
1.19 ± 0.8●●
0.76 ± 0.8
[, ]
5.904
13.440
22.802
45.331
6.833
11.008
97.701
90.914
△, △△ versus nondiabetic control (NC) of each division; ●, ●● versus N-M617 of each division; ○, ○○ versus diabetic control (DC) of each division. , versus those of before experiment of each division.
