A Novel Wistar Rat Model of Obesity-Related Nonalcoholic Fatty Liver Disease Induced by Sucrose-Rich Diet

Table 4

Linear and logistic regression models for the response variables.

Variable/model	Coefficient; (95% CI)	Coefficient; exponential (95% CI)	P value
Glucose
Constant	5.2		<0.001
Time (weeks)
5
10	0.4	1.49 (1.1; 2.0)	0.005
20	0.3	1.35 (1.0; 1.8)	0.090
30	0.5	1.65 (1.3; 2.1)	<0.001
Group
EG	0.4	1.49 (1.3; 1.8)	<0.001
CG
Total cholesterol
Constant	177.7 (139.3; 216.1)		<0.001
Time (weeks)
5
10	−25.2 (−46.8; 3.6)		0.026
20	−50.9 (−107.7; 5.9)		0.085
30	−40.2 (−84.8; 4.4)		0.083
Group
EG	19.2 (4.4; 31.2)		0.003
CG
ΔKcal	−0.1 (−0.2; −0.03)		0.014
HDL-cholesterol
Constant	53.1 (46.7; 59.5)		<0.001
Exercise
Yes	26.1 (12.9; 39.4)		<0.001
No
ΔKcal	−0.03 (−0.05; −0.01)		0.011
LDL-cholesterol
Constant	2.8 (−16.3; 21.9)		0.774
ΔBMI	60.2 (11.9; 108.6)		0.018
Insulin (first model)
Constant	0.8		<0.001
Time (weeks)
5
10	−0.005	1.00 (0.67; 1.47)	0.980
20	−1.8	0.17 (0.11; 0.24)	<0.001
30	−2.2	0.11 (0.07; 0.16)	<0.001
Group
EG	0.8	2.23 (0.18; 2.70)	<0.001
CG
Insulin (second model)
Constant	0.7		0.011
Time (quantitative)	−0.07	0.93 (0.91; 0.95)	<0.001
Group
EG	0.7	2.01 (1.65; 2.45)	<0.001
CG
ΔKcal	0.002	1.002 (1.001; 1.003)	0.004
Leptin
Constant	0.8		<0.001
Time (weeks)
5
10	−0.1	0.90 (0.61; 1.33)	0.450
20	−0.4	0.67 (0.45; 0.99)	0.047
30	−0.5	0.60 (0.41; 0.90)	0.004
Group
EG	1.3	3.67 (3.01; 4.46)	<0.001
CG
ΔBMI	2.6	13.46 (5.1; 35.87)	<0.001
Superoxide dismutase
Constant	0.7		<0.001
Time (weeks)
5
10	−0.03	0.97 (0.85; 1.11)	0.606
20	0.10	1.11 (0.96; 1.27)	0.156
30	−0.27	0.76 (0.68; 0.86)	<0.001
Group
EG	−0.12	0.89 (0.82; 0.96)	0.006
CG
ΔIMC	−0.77	0.46 (0.32; 0.67)	<0.001
Catalase
Constant	16.6 (15.0; 18.3)		<0.001
Time (weeks)
5
10	−0.7 (−2.9; 1.6)		0.564
20	−2.4 (−4.6; 0.2)		0.041
30	−0.1 (−2.1; 1.8)		0.902
Group
EG	−1.8 (−3.2; 0.4)		0.016
CG
Model/variable		Odds ratio (95% CI)	P value
Steatosis
ΔTC		1.50 (1.10; 1.90)	0.002
Hepatocellular ballooning
ΔTC		1.50 (1.10; 1.90)	0.002

EG, experimental group; CG, control group; Kcal, amount of calorie intake; TC, thoracic circumference.