The Relationship of Metabolic Syndrome Traits with Beta-Cell Function and Insulin Sensitivity by Oral Minimal Model Assessment in South Asian and European Families Residing in the Netherlands

Table 2

Relationship between metabolic syndrome traits and insulin sensitivity index (ISI), dynamic disposition index (DI), and static disposition index (DI) adjusted for sex and age according to ethnicity.

Metabolic syndrome trait	ISI	95% CI		DI	95% CI		DI	95% CI
	×10^−4 dL/kg/min per μU/mL			×10^−10 dL/kg/min per μU/mL			×10^−10 dL/kg/min per μU/mL
South Asians
Waist-to-hip ratio	−61	−109 to −13	0.015	−9.4	−27.0 to 8.1	0.284	−0.7	−1.8 to 0.3	0.181
Triglycerides (mmol/L)	−7.1	−11.9 to −2.3	0.005	−2.0	−3.7 to −0.3	0.022	−0.1	−0.2 to −0.04	0.007
HDL (mmol/L)	25.7	15.8 to 35.7	0.001	5.9	1.9 to 9.9	0.005	0.5	0.2 to 0.7	0.001
Systolic blood pressure (mmHg)	−0.2	−0.4 to −0.03	0.028	0.06	−0.1 to 0.02	0.129	−0.005	−0.009 to −0.0006	0.026
Diastolic blood pressure (mmHg)	−0.2	−0.5 to 0.1	0.169	−0.04	−0.1 to 0.07	0.487	−0.003	−0.01 to 0.003	0.281
Fasting plasma glucose (mmol/L)	−3.0	−5.3 to −0.6	0.014	−1.2	−2.0 to −0.4	0.003	−0.07	−0.1 to −0.003	0.002
Europeans
Waist-to-hip ratio	−95	−159 to −31	0.005	−25.6	−49.6 to −1.7	0.036	−22.9	−4.8 to −0.2	0.075
Triglycerides (mmol/L)	−7.9	−18 to 2.4	0.131	−0.3	−4.0 to 3.5	0.888	−0.1	−0.5 to 0.3	0.518
HDL (mmol/L)	10.6	−5.9 to 27.1	0.204	1.3	−4.7 to 7.3	0.668	0.3	−0.3 to 1.0	0.266
Systolic blood pressure (mmHg)	−0.6	−0.9 to −0.3	0.001	−0.1	−0.3 to −0.02	0.026	−0.02	−0.03 to −0.006	0.005
Diastolic blood pressure (mmHg)	−0.8	−1.3 to −0.3	0.004	−0.1	−0.3 to 0.05	0.144	−0.02	−0.04 to 0.004	0.111
Fasting plasma glucose (mmol/L)	−5.2	−10.3 to −0.09	0.046	−2.3	−4.1 to −0.5	0.01	−0.2	−0.4 to 0.005	0.056

HDL: high-density lipoprotein; ISI: insulin sensitivity index; DI: dynamic disposition index; DI: static disposition index.