High-Fat Diet Augments VPAC1 Receptor-Mediated PACAP Action on the Liver, Inducing LAR Expression and Insulin Resistance

Figure 1

Effects of HFD on glucose tolerance and insulin tolerance in wildtype and PACAP null mice. (a) and (b) Blood glucose levels in GTT in wild type (WT) (open symbols) and PACAP null mice (filled symbols) fed regular chow (a) and HFD (b) for 6 weeks. Glucose at 2 g/kg body weight was injected to mice fasted 6 h. (c) and (d) Blood glucose levels in ITT in WT and PACAP null mice fed regular chow (c) and HFD (d) for 6 weeks. Insulin at 0.5 IU/kg body weight was injected to mice fasted for 6 h. All data are presented as means ± s.e.m. .

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