Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E₂ and F₂α Metabolites, in the Offspring of Rats with Streptozotocin-Induced Diabetes

Table 6

COX activity in placentas (U/mg of protein).

Groups	Total COX		COX-1		COX-2
Vehicle-treated control (V-TC) ()
LA-treated control (LA-TC) ()
	Nonmalformed		Nonmalformed		Nonmalformed
Vehicle-treated diabetic (V-TD) ()
LA-treated diabetic (LA-TD) ()

lower () compared with placentas of nonmalformed fetuses of both groups of diabetic rats.
higher () compared with placentas of both nonmalformed and malformed fetuses of diabetic rats.
higher () than those in malformed fetuses from V-TD rats.