Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control

Table 2

Impact on HbA1c and IDAA1c by increasing genetic risk score.

Time after onset	Increase in HbA1c (%) per additional risk allele (SE)	value	Increase in IDAA1c per additional risk allele (SE)	value
1 month	0.09	0.06	—	NS
3 months	0.11 (0.04)	0.009	—	NS
6 months	0.17 (0.05)	0.0006	0.16 (0.08)	0.04
9 months	0.14 (0.05)	0.01	0.19 (0.07)	0.01
12 months	0.15 (0.06)	0.008	0.19 (0.08)	0.02

The influence of increasing risk allele number on HbA1c and IDAA1c analyzed by genetic risk score generated from 11 qualified T1D genes in linear regression analysis adjusted for age, sex, and HLA risk groups. Data are presented as increase in HbA1c (%) and IDAA1c per additional risk allele during the first year after diagnosis in 182 children with new onset T1D.