Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control

Table 3

The gene ontology terms of the 11 T1D candidate genes.

GO biological process	Reference	Count	Genes	Expected	value
Regulation of immune response	930	7	IFIH1, INS, TNFAIP3, IL7R, SKAP2, CTSH, IL10	0.49	0.0008
Negative regulation of immune response	116	4	INS, TNFAIP3, IL7R, IL10	0.06	0.002
Positive regulation of multicellular organismal process	1357	7	IFIH1, INS, TNFAIP3, COBL, IL7R, CTSH, IL10	0.72	0.01
Negative regulation of type I interferon production	43	3	IFIH1, TNFAIP3, IL10	0.02	0.01
Immune system process	2163	8	IFIH1, SH2B3, INS, TNFAIP3, IL7R, SKAP2, CTSH, IL10	1.14	0.01
Regulation of immune system process	1473	7	IFIH1, INS, TNFAIP3, IL7R, SKAP2, CTSH, IL10	0.78	0.02
Negative regulation of chronic inflammatory response	5	2	TNFAIP3, IL10	0	0.02

The enriched gene ontology (GO) terms in the biological process category are listed for the 11 candidate genes. The GO terms are followed by number of genes having the enriched term in the reference list (Reference), number of genes in the input list having the enriched term (Count), gene names for the genes listed in Count, and Bonferroni-corrected values.