The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture

Figure 10

Naltrexone treatment normalizes epithelial wound healing in diabetic rats. Residual epithelial defect up to 64 h after creation of a 5 mm corneal abrasion. DS (untreated diabetic) had significantly larger residual epithelial defects than the CS (nondiabetic) or DN (NTX-treated diabetic rats). Therefore, NTX treatment prevents the delay in wound healing of ocular surface epithelium observed in poorly controlled diabetic animals. Data are expressed as means ± SEM and represent the residual of the original defects presented as a percentage of the original wounds. Significant difference between the DS and CS groups, or . Significant difference between the DS and DN groups, or (derived from [31]).