The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture

Figure 13

Impact of NTX treatment on corneal sensitivity. (a) Prior to NTX treatment: 2-fold decreased corneal sensitivity in the 8-week DB untreated diabetic rats compared to normal controls (increased force required to generate a response). (b) After NTX treatment, DB sensitivity returned to normal levels with a 2-fold and 1.5-fold increase in sensitivity, respectively, following NTX treatment. There was no effect on corneal sensitivity and there was no effect on normal or insulin treated diabetic (DB-In) rats. Note: in both histograms, higher bar is less sensitive. Values are means ± SEM. Significantly different from NTX at and untreated corneas at (derived from [42]). Height of histogram indicates force required for stimulus to be detected. Higher histogram indicates less sensitivity.

(a)

(b)