The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture

Figure 16

Tear production in wild-type or db/db mice given one drop of 10⁻⁵ M NTX (a) or only vehicle (b). (a) Note the rise in tear production to normal levels with NTX until about 72 hrs after treatment. No effect from vehicle alone (b) with abnormal tear production at all times tested. Ocular surface abnormalities related to type 2 diabetes are reversed by the opioid antagonist naltrexone. Significantly different from measurements for corresponding wild-type mice at each time point at , , and (derived from [45]).

(a)

(b)