The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture

Figure 19

Full-thickness wound closure following application of topical NTX to normal and hyperglycemic rats. (a) Full-thickness wounds created on the dorsal surface of normal and type 1 diabetic rats. Wounds were treated three times daily with either 10⁻⁵ mol/L NTX (NTX) or saline (vehicle) dissolved in Neutrogena moisturizing cream. Photographs were taken every other day for 18 days. Bar = 5 mm. (b) Histograms of residual defects as a % of the original wounds. Groups were treated with either NTX or vehicle over an 18-day period of time. Diabetic NTX-treated rats (DB + NTX) had wounds 62–89% smaller compared to DB controls (DB + vehicle). Diabetic NTX-treated rats (DB NTX) had wounds 62–89% smaller than DB controls. Significantly different from normal + vehicle measurements at , , and ; significantly different from DB + vehicle group at and . NTX: naltrexone; DB: diabetic (derived from [65]).

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