Review Article
The Yin and Yang of the Opioid Growth Regulatory System: Focus on Diabetes—The Lorenz E. Zimmerman Tribute Lecture
Figure 21
Spontaneously diabetic db/db mice with 5 mm full-thickness skin wounds on dorsum were treated with topical 10−5 M NTX in moisturizing cream or saline dissolved in moisturizing cream TID × 14 days. (a) DNA labeling indices calculated from the number of BrdU-positive basal cells relative to the total number of basal cells. Depressed DNA synthesis is noted in the DB rats compared to normal or NTX-treated DB animals. NTX-treated DB mice had BrdU LI of 52% compared to 43% for normal and NTX-treated normal animals. Values represent mean ± SEM. Significantly different from normal + vehicle group at . Labeling indexes in NTX-treated diabetic (db/db + NTX) skin were significantly different from measurements in saline-treated tissue from T2D mice (db/db + vehicle) at . (b) Sections of the skin treated as above illustrate the relative labeling amounts of the treatment groups (derived from [67]).
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