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Journal of Diabetes Research
Volume 2016 (2016), Article ID 9726503, 10 pages
Research Article

Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats

1Medical Department, General Hospital of Jinan Military Command, 25 Shifan Road, Jinan, Shandong 250031, China
2Department of Pathophysiology, Wannan Medical College, Wuhu 241002, China
3Department of Physiology, Wannan Medical College, Wuhu 241002, China

Received 5 June 2015; Revised 7 September 2015; Accepted 13 September 2015

Academic Editor: Paolo Fiorina

Copyright © 2016 Qing-Ying Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.