The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications

Figure 1

Structure and phosphorylation residues of IR, IGF-IR, and hybrid receptors. (a) Schematic representation of IR. (Left) α chain: exons 1–10 (IRA) or exons: 1–11 (IRB) and β chain: exons 12–22. (Right) Domains of IR: L1, large domain rich in Leu; CR, domain rich in Cys; L2, large domain 2; Fn, fibronectin III type domain; TM, transmembrane domain; JM, juxtamembrane domain; TK, Tyr kinase domain; CT, C-terminal domain. In the JM, TM, TK, and CT domains, Tyr phosphorylation residues are indicated. (b and c) Schematic representations of IGF-IR isoforms (CAG⁺/CAG⁻) and hybrid receptors (IRA : IGF-IR and IRB : IGF-IR). In the figure are also indicated the different domains and Tyr phosphorylation residues.

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