Acute Elevated Glucose Promotes Abnormal Action Potential-Induced Ca²⁺ Transients in Cultured Skeletal Muscle Fibers

Figure 2

Sustained elevation of extracellular D-glucose modifies the distribution of AP-induced Ca²⁺ transients observed in 5-day-old cultured fibers. Zoomed-in and overlapped version of AP-induced Ca²⁺ transients for control (a), D-glucose (b), and L-glucose (c) challenged fibers. (d–f) Summary of distribution of AP-induced Ca²⁺ transients for fibers exposed to control isotonic medium (d), D-glucose (e), and L-glucose (f). Fibers exposed to D-glucose displayed a significantly larger proportion of biphasic action potential-induced Ca²⁺ transients when compared to control counterparts (X², , value < 0.05).

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