Journal of Diabetes Research / 2017 / Article / Fig 2

Research Article

Acute Elevated Glucose Promotes Abnormal Action Potential-Induced Ca2+ Transients in Cultured Skeletal Muscle Fibers

Figure 2

Sustained elevation of extracellular D-glucose modifies the distribution of AP-induced Ca2+ transients observed in 5-day-old cultured fibers. Zoomed-in and overlapped version of AP-induced Ca2+ transients for control (a), D-glucose (b), and L-glucose (c) challenged fibers. (d–f) Summary of distribution of AP-induced Ca2+ transients for fibers exposed to control isotonic medium (d), D-glucose (e), and L-glucose (f). Fibers exposed to D-glucose displayed a significantly larger proportion of biphasic action potential-induced Ca2+ transients when compared to control counterparts (X2, , value < 0.05).

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