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Journal of Diabetes Research
Volume 2017 (2017), Article ID 1683678, 9 pages
Review Article

Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis

Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China

Correspondence should be addressed to Yingke Xu; nc.ude.ujz@uxekgniy

Received 26 January 2017; Revised 21 March 2017; Accepted 3 April 2017; Published 26 April 2017

Academic Editor: Ping Huang

Copyright © 2017 Xiaoxu Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human. The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified. Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets.