Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice

Figure 3

Induction of UPR and inflammatory cytokines and UDCA-mediated attenuation in diabetic mice. Levels of UPR markers and inflammatory cytokines were assessed via western blot analysis of eye tissue from control (), nontreated DM (), and UDCA-treated DM () groups. (a) Representative results of western blot analyses are shown. (b) Increased levels of GRP78, pPERK, peIF2α, MCP-1, and TNF α in diabetic mice, compared to the control group, were attenuated by UDCA. ATF6 and CHOP expression was not significantly different among groups. CTL: control mice, DM: nontreated diabetic mice, and +UDCA: diabetic mice treated with UDCA, < 0.05, < 0.01, < 0.005.

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