Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice

Figure 6

mLDL-induced UPR, inflammatory cytokine expression, and cell death are attenuated by UDCA in retinal pericytes. (a) Typical results of four independent western analyses are shown. (b) Levels of pPERK, peIF2α, CHOP, and MCP-1 were increased and attenuated upon cotreatment with UDCA. GRP78, ATF6, and TNF-α did not display significant changes in expression. (c, d) PI staining demonstrating the protective effect of UDCA against cell death in mLDL-exposed retinal pericytes. Original magnification: ×100; scale bar: 100 μm. CTL: control pericytes, mLDL: mLDL-exposed pericytes, and +UDCA: mLDL-exposed pericytes cotreated with UDCA, < 0.05, < 0.001.

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