Review Article

Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective

Table 1

Studies about reported new future therapies of DN.

Study/yearDesign/numbersRaceEndpoints

Irannejad et al., 2016 [10]Retrospective single-center analysis, serum nesfatin-1 in patients, included 44 adult patients with type 2 diabetes and microalbuminuria and 44 control patients with type 2 diabetes and normoalbuminuriaAsiansPeripheral nesfatin-1 levels are markedly elevated in patients with type 2 diabetes and microalbuminuria
Katayama et al., 2016 [11]Prospective multicenter-randomized analysis, the efficacy and safety of seven once-daily oral doses of finerenone, included individuals: 96AsiansFinerenone reduced albuminuria without adverse effects on serum potassium levels or renal function
Fouad et al., 2016 [12]Retrospective single-center analysis, the relationship between serum uric acid and hypertension in DN, included individuals: 986CaucasiansSerum uric acid level may identify and link with the onset of hypertension in DN
Machingura et al., 2017 [13]Prospective cross-sectional analysis, prevalence of and factors associated with DN in Zimbabwe, included individuals: 344BlacksPrevalence of DN is higher in type 1 and type 2 diabetes mellitus patients than previously reported in Zimbabwe
Perkowska-Ptasinska et al., 2016 [14]Retrospective multicenter analysis, biopsy based data from 14 renal centers in Poland, included individuals: 352CaucasiansThe relatively high prevalence of potentially curative kidney diseases of renal biopsy in these patients
Kaidonis et al., 2016 [15]Prospective multicenter analysis, the single nucleotide polymorphism (SNP) rs2910164 residing within microRNA-146a (miR-146a) is associated with DN, included individuals: 890CaucasiansRs2910164 is significantly associated with microvascular complications DN
Li et al., 2015 [16]Prospective multicenter randomized analysis, the additional benefit and safety of the Chinese herbal granule Tangshen Formula (TSF) in treating DN, included individuals: 180AsiansTSF appears to be a safe therapeutic treatment for DN patients