Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside

Table 1

Measurements of global and macular retinal vascular diameter.

Method	Measurement	Vascular diameter before; laser treatment (μm) ± SD	Vascular diameter after; laser treatment (μm) ± SD	value
IVAN	CRAE	140.3 ± 13.2	139.3 ± 13.1	0.44
	CRVE	214.1 ± 23.6	213.1 ± 22.8	0.40
	Control CRAE	141.5 ± 14	138.6 ± 15.8	0.26
	Control CRVE	213.1 ± 24.2	214.0 ± 25.0	0.84
Modified IVAN	Macular arterioles	73.5 ± 11.2	72.0 ± 10.7	0.04
	Macular venules	63.5 ± 17.8	62.4 ± 17.6	0.02
	Control macular arterioles	71.7 ± 11.9	71.8 ± 12.2	0.89
	Control macular venules	62.0 ± 15.5	61.2 ± 15.7	0.10

Data are presented as mean with standard deviation (SD). Vessel diameters are compared before and after laser treatment with the Wilcoxon signed-rank test. Statistically significant. CRAE: central retinal arteriolar equivalent; CRVE: central retinal venular equivalent; m-IVAN: modified IVAN; MRAE: macular retinal arteriolar equivalent; MRVE: macular retinal venular equivalent [65].