Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

<div>Podocyte EMT. In elevated glucose levels, the TGF-<i>β</i>1/Smad signal pathway resulted in increased protein expression of Snail in cultured podocytes, which induced podocyte EMT. Additionally, AngII promoted translocation of <i>β</i>-catenin/LEF-1 complexes into the nucleus through the enhancement of ILK in transitioning epithelia, where they downregulated CD2AP expression via promoting EMT transcription in podocytes.</div>

Journal of Diabetes Research

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Figure 2

Figure 2: Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy 