Research Article

Selective Screening Strategies for Gestational Diabetes: A Prospective Cohort Observational Study

Table 4

Comparison of the performance of scoring systems for the screening of GDM in our population.

StudyRisk factorsRisk calculationAUROCa
(study population)
AUROCa
(original)
P20

Caliskan et al. [7](i) Age (years)
(ii) Body mass index (BMI)
(iii) Family history of diabetes mellitus (DM)
(iv) Previous baby > 4000 g
(v) Previous adverse pregnancy outcome
(i) <25 = 0; >25 = 1
(ii) <25 = 0; >25 = 1
(iii) No = 0; yes = 1
(iv) No = 0; yes = 1
(v) No = 0; yes = 1
0.5936 (0.5370–0.6504)0.832 (0.793–0.867)0.0005

Naylor et al. [8](i) Age (years)
(ii) Body mass index (BMI)
(iii) Race
(i) <30 = 0; 31–34 = 1; >35 = 2
(ii) <22 = 0; 22.1–25 = 2; >25.1 = 3
(iii) White/Black = 0; East Asian = 5; South Asian = 2
0.5897 (0.53214–0.64730)0.733 (0.711–0.755)0.0007

Van Leeuwen et al. [9](i) Body mass index (BMI)
(ii) Race
(iii) Family history of diabetes mellitus (FamHx)
(iv) Gestational diabetes in previous pregnancy (GDMHx)
=1/[1 + exp(−β)]
β = [−6.1 + (0.83 × non-Caucasian) + (0.57 × FamHx) − (0.67 × multipara no GDMhx) + (0.5 × multipara GDMhx) + (0.13 × BMI)]
(Non-Caucasian: no = 0; yes = 1
Famhx: no = 0; yes = 1
Nullipara = 0; multiparaNoGDMhx = 1; multiparaGDMhx = 2)
0.5675 (0.51–0.63)0.770 (0.690–0.850)0.0015

Phaloprakarn et al. [10](i) Age (years)
(ii) Body mass index (BMI)
(iii) Family history of diabetes mellitus (FH)
(iv) Previous baby > 4000 g
(v) Previous adverse pregnancy outcome
6 age + 11 BMI + 109FH + 42 baby > 4000 g + 49 adverse pregnancy outcome
≥380 is positive screen
0.5182 (0.48664–0.54972)0.769 (0.746–0.792)<0.001

Teede et al. [11](i) Age (years)
(ii) Body mass index (BMI)
(iii) Race
(iv) Family history of diabetes mellitus
(v) Gestational diabetes in previous pregnancy
(i) <25 = 0; 25–34 = 1; >35 = 2
(ii) <20 = 0; 20–34.9 = 1; >35 = 2
(iii) White = 0; East Asian/South Asian/African = 1
(iv) No = 0; yes = 1
(v) No = 0; yes = 2
0.5863 (0.52934–0.64334)0.703 (0.679–0.727)0.0003

Harrison et al. [12](i) Age (years)
(ii) Body mass index (BMI)
(iii) Race
(iv) Family history of diabetes mellitus
(v) Gestational diabetes in previous pregnancies
(vi) Fasting plasma glucose (FPG)
(i) <25 = 0; 25–34 = 1; >35 = 2
(ii) <20 = 0; 20–34.9 = 1; >35 = 2
(iii) White = 0; East Asian/South Asian/African = 1
(iv) No = 0; yes = 1
(v) No = 0; yes = 2
(vi) If score ≥ 3 assesses FPG
Model 1FPG 4.61–4.89 mmol/l0.4751 (0.451–0.4995)0.753 (0.675–0.832)<0.001
Model 2FPG ≥ 4.9 mmol/l0.8662 (0.8336–0.89869)0.83 (0.77–0.90)0.1846

Syngekali et al. [13](i) Gestational diabetes in previous pregnancy
(ii) Family history of DM
(iii) Age (years)
(iv) Weight (kg)
(v) Height (cm)
(vi) Race
(vii) Method of conception
(viii) Birth weight of previous pregnancy
No formula available in articleCould not be calculated as inadequate information on last pregnancy birth weight available0.823 (0.820–0.826)

Nanda et al. [14](i) Age (years)
(ii) Body mass index (BMI)
(iii) Race
(iv) Gestational diabetes in previous pregnancy
(v) Previous baby’s birth weight > 90th centile (prevBW)
=1/[1 + exp(−β)]
β = {−8.68947 + (0.05365 × age) + (0.10852 × BMI) + (1.00312 × South Asian) + (0.88785 × East Asian) + (3.72259 × previous GDM) + (0.67673 × prevBW > 90th centile)}
0.6218 (0.56301–0.68058)0.788 (0.759–0.817)<0.001

Capula et al. [15](i) Age (years)
(ii) Pregravid body mass index (BMI)
(iii) Previous gestational diabetes (GDM), polycystic ovarian syndrome (PCOS)
(iv) Fasting plasma glucose (FPG) 5.6–6.9 mmol/l before pregnancy
= Constant − 2.2532 × (age/10) + 0.4128 × (age/10)2 + 0.0795 × pregravid BMI
Constant is intercept depending on previous GDM, PCOS, FPG 5.6–6.9 mmol/l before pregnancy
0.5337 (0.48 0.59)(Information not available)

aAUROC: area under receiver operating curve.