Diabetic Retinopathy in the Spontaneously Diabetic Torii Rat: Pathogenetic Mechanisms and Preventive Efficacy of Inhibiting the Urokinase-Type Plasminogen Activator Receptor System

Figure 3

Effects of UPARANT on fluorescein leakage. (a–c) Fluorescein dextran microscopy performed soon after intraventricular injection of fluorescein solution in control SD (a) and SDT rats either vehicle-treated (b) or UPARANT-treated (c). Arrows in (b) point to hyperfluorescent areas in the retina of untreated SDT rats. In comparison with SD rats, untreated SDT rats showed abnormal retinal vasodilatation together with severe fluorescein leakage while the leakage is prevented by UPARANT administration. Scale bar: 1 mm. Fluorescein dextran microscopy was performed on 4 retinas (from untreated and vehicle-treated SDT rats) and 6 retinas (from SD control rats and UPARANT-treated SDT rats). The retinas originated from 2 or 3 different rats, respectively.

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