Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes

Table 2

Comparison of various parameters between the Zucker strains and G-K/Wistar strains.

Subject	ZL	ZF	ZDF	Wistar	G-K
Weight (g)
Glucose (mg/dL)
CD3 (%)
CD45RA (%)
CD11b/c (%)
CD11b (%)
Phagocytosis (MFI)
pERK (ratio)

All data were obtained from 16-week-old, male rats.
ZL, Zucker lean rats; ZF, Zucker fatty rats; ZDF, Zucker diabetic fatty rats.
(versus ZL rats, by one-way ANOVA, n = 4~5)
(versus Wistar rats, by Mann–Whitney test, n = 8~11)
CD3 (%) and CD45RA (%) indicate the corresponding ratios in lymphocytes.
Phagocytosis (MFI) indicates the phagocytic activity of monocytes using FITC-labeled BioParticle. MFI, mean of fluorescence intensity.
pERK (ratio) shows the ratio of phosphorylated ERK to total ERK in monocytes after stimulation with lipopolysaccharide for 10 min, as described in the text.