Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy

Figure 2

Aberrant levels of miRNAs in HRECs and ARPE-19 cells under hyperglycemia exposure for different periods. (a) In HRECs, miR-124-3p and -125b-5p were downregulated along with an increase in HG-exposure time, whereas miR-135b-5p, -145-5p, -146a-5p, and -199a-5p were first upregulated and then downregulated as compared to levels observed following NG treatment. (b) In RPE cells, HG treatment caused a gradual decline in the levels of miR-124-3p, -125b-5p, -135b-5p, and -199a-5p relative to levels observed after NG exposure. By contrast, miR-145-5p and -146a-5p levels were continually upregulated in RPE cells upon HG exposure. Treatment of HRECs and RPE cells with mannitol (MN) revealed that osmotic change exerted no effect on miRNA expression. ; ; .

(a)

(b)