Journal of Diabetes Research

Research Article

Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy

Table 1

Rat spinal cord cytokine proteome array. The levels of 29 cytokines in the lumbar spinal cord of control, diabetic, and gabapentin-treated diabetic rats. Mean values ± SD are displayed. . in a 1-way ANOVA.


Name	Mean OD ± SD						value
Name	Control		Diabetic		Diabetic + gabapentin		value

IL-1α	0.30	0.09	0.37	0.15	0.35	0.07	0.60
IL-1β	0.32	0.07	0.33	0.03	0.32	0.09	0.96
IL-1ra	0.30	0.03	0.37	0.02	0.33	0.05	0.09
IL-2	0.25	0.03	0.26	0.06	0.36	0.09	0.10
CINC-1	0.39	0.21	0.51	0.34	0.56	0.24	0.68
CINC-2	0.10	0.02	0.12	0.02	0.13	0.05	0.40
CINC-3	0.31	0.04	0.37	0.04	0.33	0.02	0.12
IFN-γ	0.31	0.05	0.29	0.02	0.27	0.02	0.19
IL-3	0.26	0.09	0.26	0.05	0.28	0.08	0.91
IL-4	0.23	0.08	0.25	0.06	0.27	0.08	0.74
IL-6	0.25	0.04	0.24	0.03	0.20	0.04	0.26
IL-10	0.25	0.08	0.22	0.03	0.24	0.04	0.82
CNTF	6.52	1.91	8.68	2.50	9.49	3.47	0.32
sICAM-1	9.18	3.28	13.10	2.74	12.80	2.63	0.15
Thymus chemokine	19.90	0.36	23.20	3.03	17.10	5.85	0.13
Fractalkine	1.02	0.24	1.00	0.18	1.02	0.27	0.99
GM-CSF	0.37	0.20	0.34	0.06	0.28	0.04	0.55
RANTES	0.29	0.06	0.40	0.13	0.40	0.09	0.22
TIMP-1	0.46	0.28	0.75	0.43	0.96	0.94	0.54
TNF-α	0.10	0.03	0.12	0.03	0.13	0.04	0.38
VEGF	0.56	0.17	0.41	0.02	0.49	0.03	0.07
CXCl5	0.71	0.1	1.1	0.31	0.72	0.15	0.07
MIG	0.36	0.07	0.35	0.04	0.33	0.07	0.81
IL-13	0.26	0.17	0.18	0.04	0.22	0.05	0.57
IL-17	0.22	0.04	0.24	0.06	0.31	0.05	0.10
MIP-1α	0.13	0.02	0.14	0.01	0.13	0.03	0.38
MIP3α	0.21	0.04	0.21	0.01	0.19	0.02	0.32
IP-10	0.27	0.04	0.33	0.01	0.30	0.03	0.06
L-Selectin	0.99	0.18	1.53	0.32	0.87	0.20

IL-1α: interleukin-1 alpha; IL-1β: interleukin-1 beta; IL-1ra: interleukin-l receptor antagonist; IL-2: interleukin-2; IL-3: interleukin-3; IL-4: interleukin-4; IL-6: interleukin-6; IL-10: interleukin-10; CNTF: ciliary neurotrophic factor; sICAM: soluble intercellular adhesion molecule; CINC-1: Cytokine-Induced Neutrophil Chemoattractant-1; CINC-2: Cytokine-Induced Neutrophil Chemoattractant-2; CINC-3: Cytokine-Induced Neutrophil Chemoattractant-3; IFN-γ: interferon-gamma; GM-CSF: granulocyte macrophage colony stimulating factor; RANTES: regulated upon activation, normal T-cell expressed and presumably secreted; TIMP-1: tissue inhibitor of metalloproteinases-1; TNF-α: tumour necrosis factor; VEGF: vascular endothelial growth factor; CXCl5: lipopolysaccharide-induced CXC; MIG: monokine induced by gamma interferon; IL-13: interleukin-13; IL-17: interleukin-17; MIP-1α: Macrophage Inflammatory Protein-1 alpha; MIP-3α: Macrophage Inflammatory Protein-3 alpha; IP-10, interferon-gamma-induced protein-10 kDa/CXC motif chemokine 10.