Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease
Effects of SDX on oxidative stress biomarker and klotho expression in the kidney of nondiabetic and diabetic rats. (a–d) Bar graphs show the changes of SOD (a), GPx (b), ROS (c), and MDA (d) levels in the renal cortex of each group. (e, f) Protein and mRNA levels of klotho are analyzed by Western blot and real-time PCR in the rat renal cortex. Data are expressed as fold of control. CON = vehicle-treated nondiabetic group; SDX = treated with 10 mg/kg/day sulodexide. #, ##, and ### versus CON. versus vehicle-treated diabetic control (DM).