Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes

Figure 2

Effects of sitagliptin treatment on diabetic nephropathy vascular lesions in an experimental model of type 2 diabetes. (a) Histopathological lesions in untreated diabetic nephropathy: Renal arteries exhibiting marked hyperplastic arteriosclerosis and thickening and detachment of the intimal layer. Endothelial cells can no longer be identified; PAS staining of a kidney section from an obese diabetic untreated ZDF rat (original magnification ×400). (b) Improvement of histopathological vascular lesions in sitagliptin-treated diabetic nephropathy: A marked reduction in total wall and intimal layer thickening, showing normal endothelial cells; PAS staining of a kidney section from an obese diabetic sitagliptin-treated ZDF rat (original magnification ×400).

(a)

(b)